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Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.

As a mitochondrial P450 system, P450c11 is dependent on two electron transfer proteins, adrenodoxin reductase and adrenodoxin that transfer 2 electrons from NADPH to the P450 for each monooxygenase reaction catalyzed by the enzyme. In most respects this process of electron transfer appears similar to that of P450scc system that catalyzes cholesterol side chain cleavage. [9] Similar to P450scc the process of electrons transfer is leaky leading to superoxide production. The rate of electron leakage during metabolism depends on the functional groups of the steroid substrate. [10]

American-born Asian graduate student, Eric Young, is lured back to college baseball field one final time, passing himself off as 10 years younger to try out for the Division 2 Volcanos. Once he makes the cut, Eric, often injured, develops a relationship with his neighbor, Jackie, an aspiring, All-American personal trainer. But when ex-boyfriend Smaller joins the baseball coaching staff, attempting to win Jackie back, Eric finds himself amidst jealousy and suspicion. As the season progresses, Eric mentors his fellow AmerAsian roommate, Frates, also a backup catcher. Although both sit the bench, they continually prepare for a big mid-season exhibition against a pro team, hoping to garner any attention from the scouts that will show. However, when competition heats up between the 2 roommates, Frates decides to take his future into his own hands. With confrontations mounting all around, Eric is forced to search deep within, where he realizes just how closely baseball has always mirrored ... Written by Roger Lim

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